CENTELLA ASIATICA EXOSOMES – A biomimetic vector component with high regenerative activity. Exosomes are extracellular vesicles secreted by plant cells and contain highly active signaling molecules: microRNAs, lipids, proteins, enzymes and peptides. Exosomes from Centella Asiatica are obtained by membrane isolation and standardized filtration. These vesicles retain the biological activity of the key components of Centella – madecassoside, asiaticoside, asiatic acid and phytosterols, while they are packaged in a natural lipid shell that provides deep and targeted penetration into the skin. Exosomes have high bioavailability, ensuring targeted delivery of regenerative signals to skin cells

The main action mechanisms of centella exosomes in repairing skin damage:

1. Stimulation of reparative processesExosomes activate the expression of genes associated with wound healing and extracellular matrix remodeling (MMPs, TIMPs, TGF-β, VEGF). This accelerates fibroblast proliferation, synthesis of collagen types I and III, as well as fibronectin and laminin – key proteins of dermal architecture.
2. Enhancement of angiogenesisDue to the activation of vascular endothelial growth factor (VEGF), exosomes contribute to the restoration of microcirculation in damaged skin, which is critically important in conditions of hypoxia after procedures (lasers, dermabrasion, chemical burns, etc.).
3. Anti-inflammatory effectCentella exosomal components reduce the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and reduce the activation of the NF-κB signaling pathway, which leads to a rapid reduction in inflammation, hyperemia and edema.
4. Strengthening the barrier functionExosomes stimulate lipid synthesis in the stratum corneum and accelerate the restoration of connections between cells, thereby helping to restore the skin barrier and reduce transepidermal water loss (TEWL).
5. Antioxidant protection and protection against photodamageAsiaticoside and madecassoside in exosomes have the ability to neutralize free radicals and enhance the activity of the skin’s own antioxidant enzymes (catalase, superoxide dismutase).

REJUVENAD™ COMPLEX (nicotinamide adenine dinucleotide in active form) – RejuveNAD is a bioavailable form of the coenzyme NAD⁺, which is crucial for mitochondrial function and activation of sirtuins, proteins that regulate cell survival, DNA repair and energy metabolism. Increasing the level of intracellular NAD⁺ helps optimize the work of the cell’s energy apparatus, strengthen antioxidant protection and restore metabolic homeostasis, which is especially important for mature and stressed skin. NAD⁺ plays a key role in the processes of cellular metabolism, energy metabolism and DNA repair. With age, its level decreases, which leads to a slowdown in cell regeneration. RejuveNAD™ complex stimulates the activity of the enzyme NAMPT, which is responsible for the synthesis of NAD⁺ in skin cells. Increasing the concentration of NAD⁺ helps optimize cell functions, improve energy metabolism and activate DNA repair processes.

Proven efficacy of the complex in vitro: reduction of DNA damage, reduction of epigenetic changes and cellular aging, improvement of cell viability. Ex vivo studies show reduction of mitochondrial damage, increase of sirtuin 1 (SIRT1) – a protein that regulates the aging process of skin cells, increase of collagen XVII levels and collagen density.

RejuveNAD is a unique component that simultaneously fights 5 signs of skin aging: mitochondrial dysfunction, cellular aging, loss of proteostasis, epigenetic changes and genomic instability

The results of clinical studies have shown that the use of RejuveNAD™ makes the skin visually younger by up to 8 years after just 42 days of use.

BIOMIMETRIC PEPTIDES:

The combined use of these peptides provides a simultaneous reduction in inflammatory processes, stimulation of the synthesis of structural proteins and prevention of the formation of new facial wrinkles.

Acetylhexapeptide 8 (Argirelin) is a biomimetic neuropeptide, a blocker of muscle contraction. It significantly reduces the activity of facial muscles, which contribute to the formation of facial wrinkles. The component works on the presynaptic principle: a chain of 6 amino acids of the hexapeptide is embedded between two processes of the muscle, repeating the SNAP25 protein site, and does not allow the processes to touch, preventing the transmission of a nerve impulse.

Palmitoyl tetrapeptide-7 is a tetrapeptide consisting of four amino acids linked to palmitic acid, which provides better penetration through the lipid barrier of the skin. It blocks the activation of NF-κB (nuclear factor kappa-B), a protein complex that plays a key role in inflammatory processes. By reducing the activity of NF-κB, the expression of genes responsible for the synthesis of IL-6 decreases, thereby reducing chronic inflammation and slowing down the skin aging process (inflames). In addition, it reduces the breakdown of the extracellular matrix (ECM) by slowing down the activity of MMP (matrix metalloproteinase) enzymes that break down collagen and other dermis proteins.

Palmitoyl tripeptide-5 (Syn-Coll) mimics natural signal peptides that activate TGF-β (transforming growth factor-beta). TGF-β is a key factor that triggers the expression of genes responsible for collagen synthesis. When palmitoyl tripeptide-5 binds to TGF-β receptors, it “turns on” the mechanism for the synthesis of new collagen. In addition, it inhibits the activity of MMP-1 (collagenase), an enzyme that breaks down collagen fibers, which helps preserve existing collagen, which helps strengthen the dermis and improve skin texture. It provides a “fibroblast-like” effect, activating reparative processes in the dermis.

ESCIN – An active component from horse chestnut seeds that has anti-inflammatory, angioprotective and anti-edema properties. Escin increases the tone of the venous wall and stabilizes the structure of the capillary endothelium by reducing the activity of enzymes (hyaluronidase, elastase) that destroy the extracellular matrix. As a result, vascular permeability decreases and plasma release into the intercellular space decreases, which effectively eliminates the pastiness and swelling of tissues characteristic of inflamed or injured areas of the skin.

Modulation of the activity of pro-inflammatory mediators (TNF-α, IL-1β), inhibition of 5-lipoxygenase and reduction of leukotriene synthesis contributes to the reduction of erythema, burning and subjective skin sensitivity, as well as slowing down the processes of chronic microinflammation that underlie aging.

Escin neutralizes reactive oxygen species and stabilizes cell membranes, protecting lipid structures from peroxidation. By improving the tone of the vascular wall and reducing congestion, escin contributes to a better supply of tissues with oxygen and nutrients. This accelerates reparative processes and increases the viability of dermis and epidermal cells.

CYANOCOBALAMIN (vitamin B12) – A water-soluble compound that plays a key role in a number of biochemical processes that affect the regeneration and functional state of the skin.

1. Support for cell division and tissue repairVitamin B12 is necessary for the synthesis of DNA and RNA through participation in the metabolism of folic acid and methionine. This is especially important for cells with a high renewal rate, such as keratinocytes and fibroblasts. In conditions of aging or skin damage, when mitotic activity is slowed down, cyanocobalamin contributes to accelerated renewal of the epidermis and regeneration of the dermal matrix.
2. Optimization of energy metabolismDue to its participation in the Krebs cycle and fatty acid metabolism, vitamin B12 supports the production of ATP in mitochondria, which is especially important when the energy capacity of mature skin cells decreases and when it is damaged. Skin needs more energy to recover when it is healing.
3. Anti-inflammatory and antioxidant actionCyanocobalamin indirectly reduces the level of homocysteine, an amino acid that can cause oxidative stress and inflammation. This reduces the activation of pro-inflammatory cytokines, which reduces the hyperreactivity of sensitive skin and prevents the destruction of collagen.
4. Neurotropic effect and restoration of skin sensitivityVitamin B12 is involved in the synthesis of myelin, which contributes to the restoration of peripheral nerve endings in the skin. This may be especially important after aggressive cosmetic procedures, during which innervation is disrupted and sensitivity increases.
5. Support of microcirculation and tissue trophismIt participates in the formation of red blood cells and improves oxygen transport, which increases oxygen nourishment and nutrient supply to tissues, accelerating healing and recovery.

MIMOSA BARK EXTRACT – It is rich in flavonoids, triterpenes and trace elements, has a pronounced angioprotective, antioxidant and regenerative effect. Enhances microcirculation, promotes accelerated epithelialization of damaged spots, activates fibroblast proliferation.

INGREDIENTS: Aqua, Propylene glycol, Propanediol, Phenoxyethanol, Helianthus annuus sprout extract, Polysorbate 20, Ammonium acryloyldimethyltaurate/VP Copolymer, Pentylene glycol, Escin, Mimosa tenuiflora bark extract, Maltodextrin, Tetrasodium glutamate diacetate, DMDM Hydantoin, Centella asiatica leaf vesicles, Glycerin, Allantoin, Parfum, Cyanocobalamin, Acetyl hexapeptide-8, Palmitoyl tripeptide-5, Palmitoyl tetrapeptide-7.

The serum has a light gel texture. Apply to cleansed face and neck skin, wait for complete absorption. Then use a mask or cream as part of the Exo Skin Repair protocol.